# Release Notes

Release Date: March 2026

These release notes describe the key changes to Illumina Preset Protocols (IPP) v2.12.

## Compatibility

Refer to [Compatibility](/instruments-and-integrations/compatibility.md#illumina-preset-protocol) under Instruments & Integrations.

## New Features & Updates

* The updated NovaSeq X Series Sequencing v2.0 protocol supports NovaSeq X Series Integration Package v1.4.0 and NovaSeq X Series On-Prem Integration Package v1.1.0.
* The updated NextSeq 1000/2000 Sequencing v2.5 protocol supports NextSeq 1000/2000 Integration Package v2.6.0
* The updated NextSeq 1000/2000 On-Prem Sequencing v1.1.0 protocol supports NextSeq 1000/2000 Integration Package v1.1.0

{% hint style="danger" %}
Conflicts may occur when upgrading from IPP v2.11 to IPP v2.12 due to new sequencing workflow for NovaSeq X Series. Refer to [IPP Integration v2.12 Manual Upgrade](/illumina-preset-protocols/ipp-v2.12/ipp-v2.12.0-manual-upgrade.md) for details.
{% endhint %}

## Additional References

Refer to these additional release notes for new features, updates and defects fixed for instrument integration protocols:

* [NovaSeq X Series On-Prem Integration v1.1.0 Release Notes](/instruments-and-integrations/novaseq-x-series/novaseqx-onprem/novaseqx-onprem-v1.1.0-release-notes.md)
* [NovaSeq X Series Integration v1.4.0 Release Notes](/instruments-and-integrations/novaseq-x-series/novaseqx/novaseqx-v1.4.0-release-notes.md)


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